Genetics, drug discovery,
and software.
I'm Greg, a computational biologist in San Diego. I use human genetics and machine learning to find drug targets, and I build apps and games in my spare time.
Selected
- Gene2Rx Medication response reports from the DNA data you already have from 23andMe or AncestryDNA. Cofounder · Web
- Pharmacogenetics at Scale: An Analysis of the UK Biobank Across 487,409 UK Biobank participants, 99.5% carry a pharmacogene phenotype that may change their response to at least one drug. Clin Pharm & Ther · 2020
- Transfer learning enables prediction of CYP2D6 haplotype function A neural network that predicts the function of CYP2D6 haplotypes from their sequence. PLoS Comp Bio · 2020
Research16
- 2023 Apolipoprotein C3 induces inflammasome activation only in its delipidated form Nature Immunology
- 2022 Large-scale functional characterization of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency Proceedings of the National Academy of Sciences
- 2021 Drug Response Pharmacogenetics for 200,000 UK Biobank Participants Pacific Symposium on Biocomputing · first author
- 2021 Genome-wide association studies in pharmacogenomics Clinical Pharmacology & Therapeutics · first author
- 2021 Opportunities and challenges for interpreting rare variation in clinically important genes American Journal of Human Genetics · first author
- 2020 Covid Fast Fax: A system for real-time triage of Covid-19 case report faxes medRxiv Preprint
- 2020 Transfer learning enables prediction of CYP2D6 haplotype function PLoS Computational Biology · first author
- 2020 Assessing Digital Phenotyping to Enhance Genetic Studies of Human Diseases American Journal of Human Genetics
- 2020 Pharmacogenetics at Scale: An Analysis of the UK Biobank Clinical Pharmacology & Therapeutics · first author
- 2020 LPA and APOE are associated with statin selection in the UK Biobank bioRxiv · first author Preprint
- 2020 Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human Cells ChemRxiv Preprint
- 2019 Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics Bioinformatics · first author
- 2019 Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges Human Mutation · first author
- 2018 Pharmacogenomics and big genomic data: from lab to clinic and back again Human Molecular Genetics
- 2018 Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study Nature Communications
- 2017 Cloud-based interactive analytics for terabytes of genomic variants data Bioinformatics · first author
Patents13
- 2025 Treatment of PLG Related Diseases and Disorders siRNA and antisense oligonucleotides targeting PLG, for conditions associated with PLG mutations. WO2026164975A1
- 2024 Treatment of CD33 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting CD33, for conditions associated with CD33 mutations. WO2026090085A1
- 2024 Treatment of CDHR3 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting CDHR3, for conditions associated with CDHR3 variants. WO2025222056A1
- 2024 Treatment of COLGALT2 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting COLGALT2, for conditions associated with COLGALT2 variants. WO2025240505A1
- 2024 Treatment of CSPG4 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting CSPG4, for conditions associated with CSPG4. WO2025240482A1
- 2024 Treatment of PLOD2 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting PLOD2, for conditions associated with PLOD2. WO2025240499A1
- 2023 Treatment of FGG Related Hearing Disorders siRNA and antisense oligonucleotides targeting FGG, for treating hearing disorders. WO2024206673A3
- 2023 Treatment of CPN1 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting CPN1, for conditions associated with CPN1 mutations. WO2025137323A1
- 2022 Treatment of HGFAC Related Diseases and Disorders siRNA and antisense oligonucleotides targeting HGFAC, for cancer and related diseases. 2 filings
- 2022 Treatment of MS4A4E Related Diseases and Disorders MS4A4E inhibitors, including siRNA and antisense oligonucleotides, for conditions associated with MS4A4E mutations. EP4540391A2
- 2022 Treatment of GPAM Related Diseases and Disorders siRNA and antisense oligonucleotides targeting GPAM, for metabolic disorders including liver and cardiovascular conditions. 2 filings
- 2022 Treatment of MTRES1 Related Diseases and Disorders Oligonucleotides, gene therapy, and small molecules targeting MTRES1, for conditions associated with MTRES1 mutations. 6 filings
- 2022 Treatment of SOS2 Related Diseases and Disorders siRNA and antisense oligonucleotides targeting SOS2, a Ras/Rho guanine nucleotide exchange factor, for related conditions. 2 filings
Software12
- 2026
Gene2Rx for iOS The Gene2Rx companion app: your pharmacogenomics report on your phone, plus medication, symptom, and mood tracking that accounts for your genetics. App · iOS · in development - 2026
Genomisaur Polygenic risk, trait, and family planning reports built from DNA data you already have, with no new test kit. App · Web - 2026
Top Set Form Check Record a barbell lift and get a letter grade, phase-by-phase feedback, coaching cues, and safety flags, then track your technique over time. App · iOS · in development - 2026
Weeve Ministry Print-ready worship aids for Catholic Mass, weddings, and funerals, with the readings filled in automatically. App · Web - 2025
GreenGauge A golf stats tracker that logs rounds quickly on the course and shows where you're losing strokes. App · iOS - 2025
Nomen A chat-based memory assistant for remembering people and details, running on Apple Intelligence with your data kept on your device. App · iOS - 2025
RateReady A Home Screen widget that shows how much house you can afford at today's mortgage rate, updated as rates change. App · iOS - 2025
Top Set Calculator One-rep max, RPE, plate, training max, and strength score calculators for lifters, in one offline app. App · iOS - 2025
Top Set Timer A workout timer for strength rest periods, HIIT, and EMOM, where rest starts when you finish your set. App · iOS - 2025
Top Set Training Runs popular strength programs like 5/3/1, GZCLP, and nSuns, and adjusts your training max from your AMRAP sets. App · iOS - 2025
Turbo Math Games Free arcade-style math games for kids that run in the browser. Game · Web - 2021
Gene2Rx A pharmacogenetics report built from your existing 23andMe, AncestryDNA, or MyHeritage data, showing how your genes may affect medication response. App · Web